A 14 year old driver came to the emergency unit with profuse watery diarrhea. He had a history of self-administration of ORS but the condition did not improve. Urgent rectal swab was taken and microbiologic analysis revealed Vibrio cholerae.
A. Cholera toxin binds to Globoside receptor of intestinal epithelium
B. cGMP level rises as a result of ADP-ribosylation of G protein
C. Hypotonic dehydration may be present
D. Chloride channels in epithelium are sensitive to intracelluar cAMP level
E. High anion gap metabolic acidosis may occur
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